Cortright’s core practice is the creation and distribution of digital and physical images using consumer or corporate software. She became renowned for making self-portrait videos that use her computer’s webcam and default effects tools, which she would then upload to YouTube and caption with spam text.

Cortright’s paintings on aluminum, linen, paper, or acrylic are created in Photoshop using painting software and appropriated images, icons, and marks. The digital files are endlessly modifiable, but at a “decisive moment” they are translated into two-dimensional objects.

Her works are included in the permanent collections of institutions such as The Pérez Museum, Miami, FL; Los Angeles County Museum of Art, CA; Hammer Museum, Los Angeles, CA; Moderna Museet, Stockholm, Sweden; and the MCA Chicago, IL.